Starting weight-loss injections like Wegovy or Zepbound can feel like a big decision—and it is. If you’re here, you might be on the brink of your first dose or already a few days in, wondering what’s normal, what’s not, and what to expect in the weeks ahead. Maybe you’re excited, maybe you’re nervous. Most likely, it’s a bit of both. That’s completely okay.
The first month on GLP-1 medications is often the most intense. Your appetite starts to shift. Your digestion changes. You might even find yourself getting full after just a few bites—or struggling with side effects you weren’t expecting. Emotionally, there might be highs and lows as you adjust not just to the physical changes but to a new rhythm of self-awareness and discipline.
This week-by-week guide is here to help you feel informed and supported through it all. From physical symptoms to mental adjustments, we’ll walk you through what others commonly experience in those first four weeks—and remind you that you’re never alone in this. Whether you’re just considering the treatment or already holding your first pen in hand, LIWLI.com is your partner through the real, human side of this journey.
Let’s get into what the first month on weight loss injections looks like so you can step forward with clarity, confidence, and care.
How GLP-1 Weight Loss Injections Work
GLP-1 medications like Wegovy and Zepbound are designed to help with weight loss by regulating appetite. GLP-1 helps your body feel fuller for longer by slowing down digestion. It also helps balance blood sugar levels, making it easier to stick to a healthy eating plan.
Why the First Month Is Important
The first month is when your body adjusts. It’s normal to experience some side effects as your system gets used to the medication, but this is also when you’ll start seeing changes in hunger and appetite. This adjustment period is key to setting the stage for lasting success.
Week-by-Week Breakdown
Week 1: Getting Started
Starting your weight-loss journey with Wegovy or Zepbound can feel like a mix of excitement and nervousness. You’ll begin at the lowest dose, so don’t expect major changes just yet. But it’s normal to start noticing a decrease in appetite, and this might help you feel more in control of your eating.
Side effects can be common as your body adjusts. You might feel some nausea, constipation, fatigue, or mild stomach discomfort. These are usually temporary and should ease up as your body gets used to the medication.
Tips
- Stay hydrated! Drink plenty of water to help ease any discomfort.
- Try eating smaller, lighter meals to prevent an upset stomach.
- Keep a journal to track any side effects and progress.
It’s normal to feel hopeful, but it might also feel overwhelming. Be patient with yourself as your body adjusts. This is a great time to check in with your LIWLI provider should any questions arise.
Week 2: Settling In
By now, your body will start adjusting to the medication. You may notice your appetite continuing to decrease. Meals might feel more satisfying, and you could feel less tempted by snacking or cravings.
Some side effects, like nausea, may persist for a while, but they should be less severe. You might also notice some changes in your bowel movements, which is common as your body adjusts.
Tips
- Eat regular, balanced meals even if you don’t feel as hungry.
- Avoid skipping meals—this helps maintain your energy levels.
- Stay hydrated to manage any digestive changes.
You might start feeling more in control, but some emotional shifts are still possible. Patience is key during this stage. It’s helpful to speak with your LIWLI provider about your nutrition as you adjust to these changes. Stay patient—everyone’s journey is different!
Week 3: Momentum Builds
By now, you may feel more in control of your food choices, and some people even start to notice small weight changes. Your appetite will likely continue to decrease, and you may find yourself feeling more energized as your body adjusts.
You might still experience occasional side effects like fatigue or mild nausea. However, many people find that these start to subside as they enter this stage.
Tips
- If you’re feeling good, try incorporating some light exercise like walking or yoga. This can boost your energy and mood.
- Continue meal prepping—having healthy options on hand can help you stick to your goals.
- If you do have fatigue, try adding small healthy snacks such as a piece of fruit or a single serving of nuts
Emotional and Mental Shifts
It’s normal to have mood shifts. Your body and hormones are adjusting, so be gentle with yourself. Stay aware of emotional eating triggers, but don’t be too hard on yourself if it happens. Consider checking in with your provider to discuss your progress and any lingering side effects. It’s also a good time to celebrate small wins with support groups or accountability buddies!
Week 4: A New Rhythm
By the fourth week, your appetite suppression should be more noticeable, and you may find that you’re naturally eating smaller portions. Side effects like nausea or stomach discomfort may also start to taper off as your body adjusts.
Many people find that the initial side effects have started to fade by now. However, if your dosage is increased at this point, you may experience some of the earlier effects again temporarily. These are usually short-lived and manageable.
Tips
- Reflect on your journey so far. Celebrate the small victories, like healthier eating habits and better portion control.
- Keep a consistent routine for meals and hydration to support your body during this phase.
You may feel more confident as you adjust to the medication’s effects. It’s normal to have days where you feel more motivated and others where you might struggle. Just remember: This is a journey, not a race. Talk with your doctor about any concerns and prepare for possible dosage increases in the coming weeks. Continue connecting with others who are on a similar path for encouragement and advice.
Common First-Month Side Effects and How to Manage Them
During the first month of weight loss injections, you may experience some side effects as your body adjusts to the medication. While these side effects are normal, it’s important to know how to manage them and when to seek help.
Common Side Effects:
- Nausea: It’s common, especially in the first few weeks as your body adjusts. Staying hydrated and eating smaller meals throughout the day can help.
- Constipation: This can be caused by changes in your appetite and eating habits. A fiber-rich diet and staying hydrated can help alleviate this.
- Fatigue: Some people report feeling more tired than usual. Make sure to rest, but also try to get light activity when you can to keep your energy levels up. Healthy single-sized portion snacks such as fruit, vegetables, and/or nuts could sometimes help.
- Headaches: This is a common side effect, often related to changes in diet, hydration, and medication. Drinking plenty of water and eating balanced meals can help.
- Acid Reflux: Some users experience mild acid reflux, which can often be managed with antacids or by avoiding certain foods that trigger reflux.
Tips and Remedies:
- Ginger Tea: Ginger is known for helping with nausea. Sipping ginger tea can be soothing when you feel queasy.
- Fiber Supplements: If you’re experiencing constipation, consider adding a fiber supplement to your routine.
- Electrolyte Drinks: Staying hydrated is crucial. Consider drinking electrolyte beverages to help with hydration and energy.
- Bland Food: Eating bland foods like rice, toast, and applesauce can help soothe your stomach and prevent nausea.
If your side effects persist or become too uncomfortable, don’t hesitate to reach out to your provider. It’s important to discuss any issues that may be affecting your well-being.
Real Talk: Emotional Shifts & Mental Health
It’s normal to feel a mix of emotions during this journey. The changes happening in your body might trigger some emotional ups and downs. You might feel frustrated, tired, or even down at times—and that’s okay. It’s part of the process, and it’s important to give yourself grace.
The medication can impact your hormones, which may cause shifts in your mood. Add in the natural stress of adjusting to new routines, and it’s easy to see how emotions can fluctuate. If you find yourself feeling overwhelmed, journaling can help you sort through those feelings. Connecting with a therapist or an accountability buddy can also provide the support you need. They’ll help you stay grounded and remind you that emotional changes are part of the process.
Be gentle with yourself—this is a big change, and it’s okay to not have everything figured out right away.
What Happens After the First Month?
Congratulations on making it through the first month! You’re probably starting to feel the rhythm of the medication and adjusting to your new routine. In the next phase, you can expect to see more noticeable changes. Your doctor may increase your dose as you move forward, and that’s perfectly normal. As your dose increases, you might hit a weight loss plateau for a while, but don’t get discouraged—it’s just part of the process.
The second month can bring more weight loss and even better results. You’ll likely notice improvements in your overall well-being, like more energy, better sleep, and clearer focus. Stay consistent, and keep tracking your progress. With support from your healthcare team and the LIWLI community, you’ll continue moving forward.
Moving Forward: Embrace Your Journey with Confidence
It’s been a month of adjustments, growth, and self-compassion. Your journey with weight loss injections is just beginning, and we’re so proud of what you’ve accomplished so far. Remember, progress doesn’t happen overnight, and that’s okay. Every small step is a victory.
Take it slow. Trust the process. And above all, be kind to yourself. Your journey is unique, and it will unfold at its own pace. As you move forward, lean on your support system, stay consistent, and celebrate your wins along the way.
Ready for the next step? You’ve got this! Stay connected with the LIWLI community for the expert guidance, support, and motivation you need to keep moving forward. Don’t hesitate to reach out—we’re here to help you every step of the way. Sign up today and continue your journey with confidence.